How Does TRT (Testosterone Replacement Therapy) Impact Fertility ?
The same testosterone that helps deal with ED (Erectile Dysfunction), increase libido, build muscle tone, improve mood and reduce fatigue has a downside — infertility. A paradox, that the same hormone that positively impacts sexual function negatively impacts fertility when administered externally. It acts more as a contraceptive when it is not produced by the body itself. External source of testosterone disrupts th e hypothalamic-pituitary gonadal axis, (HPG axis) which is like a traffic cop directing traffic. This in turn inhibits production of luteinizing hormone and follicle stimulating hormone which suppresses natural synthesis of testosterone affecting sperm generation in the testes. Lack of natural testosterone also causes testicular shrinkage which affects the leydig cells that synthesize testosterone in the testicles. This intra-testicular process of testosterone synthesizing also plays an important role in sperm quality & motility, which is affected by the sup...