Why Are Estrogen Blockers Prescribed for TRT Patients?

External testosterone from TRT after a while, might increase estrogen levels from aromatization which needs to be countered. Too much estrogen can lead to side effects such as gynecomastia or male breasts, high water retention among other side effects. ​

Men are from Mars and women might be from Venus, but hey, we all share the same hormones, but in different proportions. Estrogen (E) is also crucial for men’s health as much as women’s though. Maintaining hormonal balance of different hormones as nature intended while optimizing deficits should be the goal of TRT for men. ​

One of the reasons TRT patients are monitored diligently at ON MEN via blood work and quarterly check ups is also to monitor estrogen levels. Means not eliminating estrogen from the body, but making sure the proper proportions of hormones are maintained for optimum health. ​

Testosterone is the most significant hormone for male sexual development and function. Naturally in males, testosterone levels decline with age, and estrogen levels increase. When large fluctuations of testosterone production occur, such as when anabolic steroids are injected, this creates an imbalance of hormones in the body. The body then corrects such an imbalance by aromatization or converting testosterone into estradiol, a form of estrogen. ​

Higher the levels of anabolic steroids imbibed, higher amounts of estrogen synthesized. Bodybuilders inject high doses of anabolic steroids, hence the aromatization of testosterone into estrogen is also very high. ​

Estrogen is synthesized from testosterone. TRT over a period increases testosterone which can lead to excess estrogen in men which is not a good thing. ​

Aromatization is the biochemical process in which an aromatase enzyme catalyzes or speeds up the conversion of testosterone into estradiol, the fundamental pathway for the synthesis of estrogens. ​

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